PATENTS AND PUBLICATIONS

nanoBioSciences, LLC is prosecuting several patent applications covering the design, use and manufacture of its AdminPatch^tm transdermal system.  The following applications are published.  Other applications may be provided to selected parties on a confidential basis.

WO2008067290 A2
TISSUE CONFORMING MICRONEEDLE ARRAY AND PATCH FOR TRANSDERMAL DRUG DELIVERY OR BIOLOGICAL FLUID COLLECTION

Inventor(s): Yuzhakov, Vadim
Abstract:
Microneedle arrays are provided for use on a contoured or flexible tissue surface. In one embodiment, the microneedle array includes a plurality of microneedles, each having a base portion, a tip end portion distal to the base portion, and body portion therebetween; and a flexible substrate which comprises a plurality of apertures, each of which are defined by (i) a plurality of substrate elements which are integral with the base portions of the microneedles, and (ii) at least one spring element connecting at least two of the substrate elements. The spring element may include a curved element, such as a C-shaped, U-shaped, or S-shaped element. Apertures may be defined, for example, by two substrate elements, which connected to three or four spring elements. A skin patch is provided for therapeutic or diagnostic applications, which includes the microneedle array and an adhesive material.

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US20080125743 A1
Tissue Conforming Microneedle Array and Patch For Transdermal Drug Delivery or Biological Fluid Collection
Inventor(s): Yuzhakov, Vadim
Abstract:
Microneedle arrays are provided for use on a contoured or flexible tissue surface. In one embodiment, the microneedle array includes a plurality of microneedles, each having a base portion, a tip end portion distal to the base portion, and body portion therebetween; and a flexible substrate which comprises a plurality of apertures, each of which are defined by (i) a plurality of substrate elements which are integral with the base portions of the microneedles, and (ii) at least one spring element connecting at least two of the substrate elements. The spring element may include a curved element, such as a C-shaped, U-shaped, or S-shaped element. Apertures may be defined, for example, by two substrate elements, which connected to three or four spring elements. A skin patch is provided for therapeutic or diagnostic applications, which includes the microneedle array and an adhesive material.

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WO2007081430
MICRONEEDLE ARRAY, PATCH, AND APPLICATOR FOR TRANSDERMAL DRUG DELIVERY
Inventor(s): Yuzhakov, Vadim
Abstract:
Microneedle array devices are provided for transdermal drug delivery. The device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has a channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In one embodiment, each microneedle has a rectangular cross-sectional shape, an untapered base portion, a tapered tip end portion, and a channel which is open to two opposing surfaces of the microneedle and extends through the body portion into the tapered tip portion.

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US20070161964 A1
Microneedle array, patch, and applicator for transdermal drug delivery
Inventor(s): Yuzhakov, Vadim

Abstract:
Microneedle arrays and drug delivery devices are provided for transdermally delivering a drug formulation to a patient. The microneedle array device includes a substantially planar substrate having an array of apertures; and a plurality of microneedles projecting at angle from the planar substrate, the microneedles having a base portion integrally connected to the substrate, a tip end portion distal to the base portion, and body portion therebetween, wherein each microneedle has at least one channel extending substantially from the base portion through at least a part of the body portion, the channel being open along at least part of the body portion and in fluid communication with at least one of the apertures in the substrate. In a preferred embodiment, each microneedle has a substantially rectangular cross-sectional shape and the channel is open to two opposing surfaces of the microneedle.

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